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    Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like Signaling.

    Domenech A, Slager J, Veening JW

    Cell Rep. 2018 Nov 27. doi: 10.1016/j.celrep.2018.11.007

    High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions.

    Aprianto R, Slager J, Holsappel S, Veening JW

    Nucleic Acids Res. 2018 Nov 2. 10.1093/nar/gky750

    Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39.

    Slager J, Aprianto R, Veening JW

    Nucleic Acids Res. 2018 Nov 2. 10.1093/nar/gky725

    Function of BriC peptide in the pneumococcal competence and virulence portfolio.

    Aggarwal SD, Eutsey R, West-Roberts J, Domenech A, Xu W, Abdullah IT, Mitchell AP, Veening JW, Yesilkaya H, Hiller NL

    PLoS Pathog. 2018 Oct. doi: 10.1371/journal.ppat.1007328

    Eavesdropping and crosstalk between secreted quorum sensing peptide signals that regulate bacteriocin production in Streptococcus pneumoniae.

    Miller EL, Kjos M, Abrudan MI, Roberts IS, Veening JW, Rozen DE

    ISME J. 2018 Oct. doi: 10.1038/s41396-018-0178-x

    CozEa and CozEb play overlapping and essential roles in controlling cell division in Staphylococcus aureus.

    Stamsås GA, Myrbråten IS, Straume D, Salehian Z, Veening JW, Håvarstein LS, Kjos M

    Mol Microbiol.. 2018 Sep. doi: 10.1111/mmi.13999

    Editorial overview: Bacterial cell regulation: from genes to complex environments.

    Veening JW, Tamayo R

    Curr Opin Microbiol. 2018 Apr. doi: 10.1016/j.mib.2018.01.005


    Quorum sensing integrates environmental cues, cell density and cell history to control bacterial competence.

    Moreno-Gámez S, Sorg RA, Domenech A, Kjos M, Weissing FJ, van Doorn GS, Veening JW

    Nat Commun. 2017 Oct 11. 10.1038/s41467-017-00903-y

    Interbacterial predation as a strategy for DNA acquisition in naturally competent bacteria.

    Veening JW, Blokesch M

    Nat Rev Microbiol. 2017 Oct. doi: 10.1038/nrmicro.2017.66

    Chromosome segregation drives division site selection in Streptococcus pneumoniae.

    van Raaphorst R, Kjos M, Veening JW

    Proc Natl Acad Sci U S A. 2017 Jul 18. 10.1073/pnas.1620608114

    Transcriptional Repressor PtvR Regulates Phenotypic Tolerance to Vancomycin in Streptococcus pneumoniae.

    Liu X, Li JW, Feng Z, Luo Y, Veening JW, Zhang JR

    J Bacteriol. 2017 Jul 15. pii: e00054-17. doi: 10.1128/JB.00054-17

    Neutrophilic NLRP3 inflammasome-dependent IL-1β secretion regulates the γδT17 cell response in respiratory bacterial infections.

    Hassane M, Demon D, Soulard D, Fontaine J, Keller LE, Patin EC, Porte R, Prinz I, Ryffel B, Kadioglu A, Veening JW, Sirard JC, Faveeuw C, Lamkanfi M, Trottein F, Paget C

    Mucosal Immunol. 2017 Jul. doi: 10.1038/mi.2016.113

    High-throughput CRISPRi phenotyping identifies new essential genes in Streptococcus pneumoniae.

    Liu X, Gallay C, Kjos M, Domenech A, Slager J, van Kessel SP, Knoops K, Sorg RA, Zhang JR, Veening JW

    Mol Syst Biol. 2017 May 10. 10.15252/msb.20167449

    Pentapeptide-rich peptidoglycan at the Bacillus subtilis cell-division site.

    Morales Angeles D, Liu Y, Hartman AM, Borisova M, de Sousa Borges A, de Kok N, Beilharz K, Veening JW, Mayer C, Hirsch AK, Scheffers DJ

    Mol Microbiol. 2017 Apr. 10.1111/mmi.13629

    Bicyclic enol cyclocarbamates inhibit penicillin-binding proteins.

    Dockerty P, Edens JG, Tol MB, Morales Angeles D, Domenech A, Liu Y, Hirsch AK, Veening JW, Scheffers DJ, Witte MD

    Org Biomol Chem. 2017 Jan 25. doi: 10.1039/c6ob01664b


    Collective Resistance in Microbial Communities by Intracellular Antibiotic Deactivation.

    Sorg RA, Lin L, van Doorn GS, Sorg M, Olson J, Nizet V, Veening JW

    PLoS Biol. 2016 Dec. 10.1371/journal.pbio.2000631

    Hard-Wired Control of Bacterial Processes by Chromosomal Gene Location.

    Slager J, Veening JW

    Trends Microbiol. 2016 Oct. 10.1016/j.tim.2016.06.003

    Time-resolved dual RNA-seq reveals extensive rewiring of lung epithelial and pneumococcal transcriptomes during early infection.

    Aprianto R, Slager J, Holsappel S, Veening JW

    Genome Biol. 2016 Sep 27. 10.1186/s13059-016-1054-5

    Infection of zebrafish embryos with live fluorescent Streptococcus pneumoniae as a real-time pneumococcal meningitis model.

    Jim KK, Engelen-Lee J, van der Sar AM, Bitter W, Brouwer MC, van der Ende A, Veening JW, van de Beek D, Vandenbroucke-Grauls CM

    J Neuroinflammation. 2016 Aug 19. 10.1186/s12974-016-0655-y

    A putative amino acid transporter determines sensitivity to the two-peptide bacteriocin plantaricin JK.

    Oppegård C, Kjos M, Veening JW, Nissen-Meyer J, Kristensen T

    Microbiologyopen. 2016 Aug. 10.1002/mbo3.363

    Highly conserved nucleotide phosphatase essential for membrane lipid homeostasis in Streptococcus pneumoniae.

    Kuipers K, Gallay C, Martínek V, Rohde M, Martínková M, van der Beek SL, Jong WS, Venselaar H, Zomer A, Bootsma H, Veening JW, de Jonge MI

    Mol Microbiol. 2016 Jul. 10.1111/mmi.13312

    Expression of Streptococcus pneumoniae Bacteriocins Is Induced by Antibiotics via Regulatory Interplay with the Competence System.

    Kjos M, Miller E, Slager J, Lake FB, Gericke O, Roberts IS, Rozen DE, Veening JW

    PLoS Pathog. 2016 Feb. 10.1371/journal.ppat.1005422


    Microscale insights into pneumococcal antibiotic mutant selection windows.

    Sorg RA, Veening JW

    Nat Commun. 2015 Oct 30. 10.1038/ncomms9773

    Red Fluorescent Proteins for Gene Expression and Protein Localization Studies in Streptococcus pneumoniae and Efficient Transformation with DNA Assembled via the Gibson Assembly Method.

    Beilharz K, van Raaphorst R, Kjos M, Veening JW

    Appl Environ Microbiol. 2015 Oct. 10.1128/AEM.02033-15

    Autophosphorylation of the Bacterial Tyrosine-Kinase CpsD Connects Capsule Synthesis with the Cell Cycle in Streptococcus pneumoniae.

    Nourikyan J, Kjos M, Mercy C, Cluzel C, Morlot C, Noirot-Gros MF, Guiral S, Lavergne JP, Veening JW, Grangeasse C

    PLoS Genet. 2015 Sep. 10.1371/journal.pgen.1005518

    The ParB-parS Chromosome Segregation System Modulates Competence Development in Streptococcus pneumoniae.

    Attaiech L, Minnen A, Kjos M, Gruber S, Veening JW

    MBio. 2015 Jun 30. 10.1128/mBio.00662-15

    Gene expression platform for synthetic biology in the human pathogen Streptococcus pneumoniae.

    Sorg RA, Kuipers OP, Veening JW

    ACS Synth Biol. 2015 Mar 20. doi: 10.1021/sb500229s

    Bright fluorescent Streptococcus pneumoniae for live-cell imaging of host-pathogen interactions.

    Kjos M, Aprianto R, Fernandes VE, Andrew PW, van Strijp JA, Nijland R, Veening JW

    J Bacteriol. 2015 Mar. 10.1128/JB.02221-14

    To mutate or not to mutate: genetic and epigenetic heterogeneity contribute to bacterial adaptation (comment on DOI 10.1002/bies.201400153).

    Veening JW

    Bioessays. 2015 Feb. doi: 10.1002/bies.201400192

    Single cell FRET analysis for the identification of optimal FRET-pairs in Bacillus subtilis using a prototype MEM-FLIM system.

    Detert Oude Weme RG, Kovács ÁT, de Jong SJ, Veening JW, Siebring J, Kuipers OP

    PLoS One. 2015. 10.1371/journal.pone.0123239

    Host glycan sugar-specific pathways in Streptococcus pneumoniae: galactose as a key sugar in colonisation and infection [corrected].

    Paixão L, Oliveira J, Veríssimo A, Vinga S, Lourenço EC, Ventura MR, Kjos M, Veening JW, Fernandes VE, Andrew PW, Yesilkaya H, Neves AR

    PLoS One. 2015. 10.1371/journal.pone.0121042


    Bacillus subtilis biosensor engineered to assess meat spoilage.

    Daszczuk A, Dessalegne Y, Drenth I, Hendriks E, Jo E, van Lente T, Oldebesten A, Parrish J, Poljakova W, Purwanto AA, van Raaphorst R, Boonstra M, van Heel A, Herber M, van der Meulen S, Siebring J, Sorg RA, Heinemann M, Kuipers OP, Veening JW

    ACS Synth Biol. 2014 Dec 19. doi: 10.1021/sb5000252

    What makes the lac-pathway switch: identifying the fluctuations that trigger phenotype switching in gene regulatory systems.

    Bhogale PM, Sorg RA, Veening JW, Berg J

    Nucleic Acids Res. 2014 Oct. 10.1093/nar/gku839

    Sensitivity to the two-peptide bacteriocin lactococcin G is dependent on UppP, an enzyme involved in cell-wall synthesis.

    Kjos M, Oppegård C, Diep DB, Nes IF, Veening JW, Nissen-Meyer J, Kristensen T

    Mol Microbiol. 2014 Jun. 10.1111/mmi.12632

    Streptococcus pneumoniae PBP2x mid-cell localization requires the C-terminal PASTA domains and is essential for cell shape maintenance.

    Peters K, Schweizer I, Beilharz K, Stahlmann C, Veening JW, Hakenbeck R, Denapaite D

    Mol Microbiol. 2014 May. 10.1111/mmi.12588

    Antibiotic-induced replication stress triggers bacterial competence by increasing gene dosage near the origin.

    Slager J, Kjos M, Attaiech L, Veening JW

    Cell. 2014 Apr 10. 10.1016/j.cell.2014.01.068

    Tracking of chromosome dynamics in live Streptococcus pneumoniae reveals that transcription promotes chromosome segregation.

    Kjos M, Veening JW

    Mol Microbiol. 2014 Mar. 10.1111/mmi.12517

    Interlinked sister chromosomes arise in the absence of condensin during fast replication in B. subtilis.

    Gruber S, Veening JW, Bach J, Blettinger M, Bramkamp M, Errington J

    Curr Biol. 2014 Feb 3. 10.1016/j.cub.2013.12.049

    Control of transcription elongation by GreA determines rate of gene expression in Streptococcus pneumoniae.

    Yuzenkova Y, Gamba P, Herber M, Attaiech L, Shafeeq S, Kuipers OP, Klumpp S, Zenkin N, Veening JW

    Nucleic Acids Res. 2014. 10.1093/nar/gku790


    Balanced transcription of cell division genes in Bacillus subtilis as revealed by single cell analysis.

    Trip EN, Veening JW, Stewart EJ, Errington J, Scheffers DJ

    Environ Microbiol. 2013 Dec. doi: 10.1111/1462-2920.12148

    The localization of key Bacillus subtilis penicillin binding proteins during cell growth is determined by substrate availability.

    Lages MC, Beilharz K, Morales Angeles D, Veening JW, Scheffers DJ

    Environ Microbiol. 2013 Dec. doi: 10.1111/1462-2920.12206

    Benchmarking various green fluorescent protein variants in Bacillus subtilis, Streptococcus pneumoniae, and Lactococcus lactis for live cell imaging.

    Overkamp W, Beilharz K, Detert Oude Weme R, Solopova A, Karsens H, Kovács Á, Kok J, Kuipers OP, Veening JW

    Appl Environ Microbiol. 2013 Oct. 10.1128/AEM.02033-13

    How to get (a)round: mechanisms controlling growth and division of coccoid bacteria.

    Pinho MG, Kjos M, Veening JW

    Nat Rev Microbiol. 2013 Sep. doi: 10.1038/nrmicro3088

    A single amino acid substitution in the MurF UDP-MurNAc-pentapeptide synthetase renders Streptococcus pneumoniae dependent on CO2 and temperature.

    Burghout P, Quintero B, Bos L, Beilharz K, Veening JW, de Jonge MI, van der Linden M, van der Ende A, Hermans PW

    Mol Microbiol. 2013 Aug. 10.1111/mmi.12292

    Spo0A regulates chromosome copy number during sporulation by directly binding to the origin of replication in Bacillus subtilis.

    Boonstra M, de Jong IG, Scholefield G, Murray H, Kuipers OP, Veening JW

    Mol Microbiol. 2013 Feb. 10.1111/mmi.12141

    Noise and Stochasticity in Gene Expression: A Pathogenic Fate Determinant

    Mikkel Girke Jørgensen, Renske van Raaphorst, Jan-Willem Veening

    Methods in Microbiology, volume 40: Microbial Synthetic Biology. 2013.


    Single cell analysis of gene expression patterns during carbon starvation in Bacillus subtilis reveals large phenotypic variation.

    de Jong IG, Veening JW, Kuipers OP

    Environ Microbiol. 2012 Dec. doi: 10.1111/j.1462-2920.2012.02892.x

    Control of cell division in Streptococcus pneumoniae by the conserved Ser/Thr protein kinase StkP.

    Beilharz K, Nováková L, Fadda D, Branny P, Massidda O, Veening JW

    Proc Natl Acad Sci U S A. 2012 Apr 10. 10.1073/pnas.1119172109


    SMC is recruited to oriC by ParB and promotes chromosome segregation in Streptococcus pneumoniae.

    Minnen A, Attaiech L, Thon M, Gruber S, Veening JW

    Mol Microbiol. 2011 Aug. 10.1111/j.1365-2958.2011.07722.x

    Live Cell Imaging of Bacillus subtilis and Streptococcus pneumoniae using Automated Time-lapse Microscopy.

    de Jong IG, Beilharz K, Kuipers OP, Veening JW

    J Vis Exp. 2011 Jul 28. 10.3791/3145

    DnaA and ORC: more than DNA replication initiators.

    Scholefield G, Veening JW, Murray H

    Trends Cell Biol. 2011 Mar. doi: 10.1016/j.tcb.2010.10.006


    Gene position within a long transcript as a determinant for stochastic switching in bacteria.

    Veening JW, Kuipers OP

    Mol Microbiol. 2010 Apr. 10.1111/j.1365-2958.2010.07113.x

    Heterochronic phosphorelay gene expression as a source of heterogeneity in Bacillus subtilis spore formation.

    de Jong IG, Veening JW, Kuipers OP

    J Bacteriol. 2010 Apr. 10.1128/JB.01484-09

    Transformation of environmental Bacillus subtilis isolates by transiently inducing genetic competence.

    Nijland R, Burgess JG, Errington J, Veening JW

    PLoS One. 2010 Mar 16. 10.1371/journal.pone.0009724


    Cellular localization of choline-utilization proteins in Streptococcus pneumoniae using novel fluorescent reporter systems.

    Eberhardt A, Wu LJ, Errington J, Vollmer W, Veening JW

    Mol Microbiol. 2009 Oct. 10.1111/j.1365-2958.2009.06872.x

    A mechanism for cell cycle regulation of sporulation initiation in Bacillus subtilis.

    Veening JW, Murray H, Errington J

    Genes Dev. 2009 Aug 15. 10.1101/gad.528209

    Two-step assembly dynamics of the Bacillus subtilis divisome.

    Gamba P, Veening JW, Saunders NJ, Hamoen LW, Daniel RA

    J Bacteriol. 2009 Jul. 10.1128/JB.01758-08


    Bet-hedging and epigenetic inheritance in bacterial cell development.

    Veening JW, Stewart EJ, Berngruber TW, Taddei F, Kuipers OP, Hamoen LW

    Proc Natl Acad Sci U S A. 2008 Mar 18. 10.1073/pnas.0700463105

    Phenotypic Variation and Bistable Switching in Bacteria

    Wiep Klaas Smits, Jan-Willem Veening, Oscar P. Kuipers

    Bacterial Physiology pp 339-365. 2008.

    Bistability, epigenetics, and bet-hedging in bacteria.

    Veening JW, Smits WK, Kuipers OP

    Annu Rev Microbiol. 2008. doi: 10.1146/annurev.micro.62.081307.163002

    Transient heterogeneity in extracellular protease production by Bacillus subtilis.

    Veening JW, Igoshin OA, Eijlander RT, Nijland R, Hamoen LW, Kuipers OP

    Mol Syst Biol. 2008. 10.1038/msb.2008.18


    Production and secretion stress caused by overexpression of heterologous alpha-amylase leads to inhibition of sporulation and a prolonged motile phase in Bacillus subtilis.

    Lulko AT, Veening JW, Buist G, Smits WK, Blom EJ, Beekman AC, Bron S, Kuipers OP

    Appl Environ Microbiol. 2007 Aug. 10.1128/AEM.00472-07

    Temporal separation of distinct differentiation pathways by a dual specificity Rap-Phr system in Bacillus subtilis.

    Smits WK, Bongiorni C, Veening JW, Hamoen LW, Kuipers OP, Perego M

    Mol Microbiol. 2007 Jul. 10.1111/j.1365-2958.2007.05776.x

    The iturin and fengycin families of lipopeptides are key factors in antagonism of Bacillus subtilis toward Podosphaera fusca.

    Romero D, de Vicente A, Rakotoaly RH, Dufour SE, Veening JW, Arrebola E, Cazorla FM, Kuipers OP, Paquot M, Pérez-García A

    Mol Plant Microbe Interact. 2007 Apr. 10.1094/MPMI-20-4-0430

    A derepression system based on the Bacillus subtilis sporulation pathway offers dynamic control of heterologous gene expression.

    Nijland R, Veening JW, Kuipers OP

    Appl Environ Microbiol. 2007 Apr. 10.1128/AEM.02266-06


    Single cell analysis of gene expression patterns of competence development and initiation of sporulation in Bacillus subtilis grown on chemically defined media.

    Veening JW, Smits WK, Hamoen LW, Kuipers OP

    J Appl Microbiol. 2006 Sep. 10.1111/j.1365-2672.2006.02911.x

    Transformation of undomesticated strains of Bacillus subtilis by protoplast electroporation.

    Romero D, Pérez-García A, Veening JW, de Vicente A, Kuipers OP

    J Microbiol Methods. 2006 Sep. 10.1016/j.mimet.2006.01.005

    Phenotypic variation in bacteria: the role of feedback regulation.

    Smits WK, Kuipers OP, Veening JW

    Nat Rev Microbiol. 2006 Apr.

    Effects of phosphorelay perturbations on architecture, sporulation, and spore resistance in biofilms of Bacillus subtilis.

    Veening JW, Kuipers OP, Brul S, Hellingwerf KJ, Kort R

    J Bacteriol. 2006 Apr. 10.1128/JB.188.8.3099-3109.2006


    Development and characterization of a subtilin-regulated expression system in Bacillus subtilis: strict control of gene expression by addition of subtilin.

    Bongers RS, Veening JW, Van Wieringen M, Kuipers OP, Kleerebezem M

    Appl Environ Microbiol. 2005 Dec. 10.1128/AEM.71.12.8818-8824.2005

    Phosphatases modulate the bistable sporulation gene expression pattern in Bacillus subtilis.

    Veening JW, Hamoen LW, Kuipers OP

    Mol Microbiol. 2005 Jun. 10.1111/j.1365-2958.2005.04659.x


    Visualization of differential gene expression by improved cyan fluorescent protein and yellow fluorescent protein production in Bacillus subtilis.

    Veening JW, Smits WK, Hamoen LW, Jongbloed JD, Kuipers OP

    Appl Environ Microbiol. 2004 Nov. 10.1128/AEM.70.11.6809-6815.2004

    The Bacillus secretion stress response is an indicator for alpha-amylase production levels.

    Westers H, Darmon E, Zanen G, Veening JW, Kuipers OP, Bron S, Quax WJ, van Dijl JM

    Lett Appl Microbiol. 2004. 10.1111/j.1472-765X.2004.01539.x


    The extracellular proteome of Bacillus subtilis under secretion stress conditions.

    Antelmann H, Darmon E, Noone D, Veening JW, Westers H, Bron S, Kuipers OP, Devine KM, Hecker M, van Dijl JM

    Mol Microbiol. 2003 Jul.