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    Our latest work on the cover of Cell Reports!

    November 27 2018

    Our work (Arnau & Jelle's) on the identification of a new (3rd) mechanism by which certain antibiotics induce pneumococcal competence for DNA uptake on the cover of Cell Reports!

    Drugs targeting PBP3 promote chain formation. Cell chains retain, rather than diffuse, the quorum-sensing peptide CSP. Chaining populations feature a longer competence and transformation time window.

    Here is the link to the paper

    See a general audience write up on our work from the University of Lausanne here (in French) 'Le pneumocoque ou l’art de déjouer les antibiotiques'

    And for a nice interview with Jelle (in Dutch and English) 'Hoe antibiotica helpen bij verspreiden van resistentie', click here

    New transnational JPIAMR grant awarded!

    November 12 2018

    Our JPIAMR (Joint Program Initiative on Antimicrobial Resistance) proposal entitled DISRUPT was selected for funding! Out of 104 applications, 10 were selected for funding. Read more here: https://www.jpiamr.eu/6th-jpiamr-joint-call-results/

    DISRUPT is coordinated by former Veeninglab post-doc Morten Kjos (now associate professor at the Norwegian University of Life Sciences) and, besides our lab, includes the teams of Nassos Typas and Christophe Merten, both from the EMBL in Heidelberg.

    The idea of DISRUPT is to fight antimicrobial resistant infections by high-throughput discovery of biofilm-disrupting agents and mechanisms. The project will start in 2019 and our lab will be funded via the SNF.

    PneumoBrowse and PneumoExpress made it to the cover of NAR!

    November 02 2018

    Our back2back papers () & () made it to the cover ! It's an artistic rendering by & of correlated gene expression in S.pneumoniae and a section of the newly assembled genome.

    BSc student invasion!

    October 24 2018

    Welcome to Aya, Gilles, Guillaume, Mam Malick and Marina, who are in their 3rd year of biology BSc, doing the 'Experimental Design' course in our lab.

    They will be working with Clement the coming weeks to figure out how CcrZ localizes. Good luck!

    New paper in PLoS Pathogens

    October 12 2018

    Interesting new work by the team of Luisa Hiller, with a small contribution by our lab (Arnau), now out in PLoS Pathogens! We show that a small peptide now called BriC, is under competence control and secreted by ComAB and plays an important role in biofilm formation. Pneumococci without BriC also colonize mice less well. Lot's of things still to learn, but again highlighting the importance of competence development for the pneumococcal lifestyle. Read the original paper here, and a news coverage item here.

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    Research

    The Veening lab is interested in understanding fundamental processes in the pneumococcus with the long-term goal to come up with new strategies to prevent and treat pneumococcal infections.

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    Teaching

    We host BSc and MSc students for their lab rotations, are involved in various practical workshops and teach in several undergraduate courses.

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    Alumni

    Meet our former team members here.

     

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    Resources

    • You can find links to most of our data here, our collaborators, as well as our Addgene and BGSC pages. Also, see some useful pages for things to do around Lausanne.
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    Join Us!

    We are always interested in motivated people. So contact us for possibilities to work in the lab!

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    Contact

    How to find us, contact us and send stuff to us.

     

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    Job openings

    We are hiring!

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    Equipment

    Equipment and facilities available for the Veening lab.

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    Jan-Willem Veening

    Group leader

    Rieza Aprianto

    Post-doc

    Afonso Bravo

    PhD candidate

    Olivier Bützberger

    First step MSc student

    Julien Denereaz

    MSc student

    Arnau Domenech

    Post-doc

    Clement Gallay

    PhD candidate

    Paddy Gibson

    PhD candidate

    Lance Keller

    Post-doc

    Jun Kurushima

    Post-doc

    Xue Liu

    Post-doc

    Renske van Raaphorst

    PhD candidate

    Monica Rengifo Gonzalez

    Lab manager

    Anne-Stéphanie Rueff

    Post-doc

    Stefano Sanselicio

    Post-doc

    Jelle Slager

    PhD candidate

    Dimitra Synefiaridou

    PhD candidate

    Vishwachi Tripathi

    MSc student

    Putri Utari

    Post-doc

    Alice Wallef

    MSc student
    Jan-Willem Veening
    Group leader
    Rieza Aprianto
    Post-doc
    Afonso Bravo
    PhD candidate
    Olivier Bützberger
    First step MSc student
    Julien Denereaz
    MSc student
    Arnau Domenech
    Post-doc
    Clement Gallay
    PhD candidate
    Paddy Gibson
    PhD candidate
    Lance Keller
    Post-doc
    Jun Kurushima
    Post-doc
    Xue Liu
    Post-doc
    Renske van Raaphorst
    PhD candidate
    Monica Rengifo Gonzalez
    Lab manager
    Anne-Stéphanie Rueff
    Post-doc
    Stefano Sanselicio
    Post-doc
    Jelle Slager
    PhD candidate
    Dimitra Synefiaridou
    PhD candidate
    Vishwachi Tripathi
    MSc student
    Putri Utari
    Post-doc
    Alice Wallef
    MSc student

    Latest publications

    Antibiotic-Induced Cell Chaining Triggers Pneumococcal Competence by Reshaping Quorum Sensing to Autocrine-Like Signaling.

    Domenech A, Slager J, Veening JW.

    Cell Rep. 2018 Nov 27. 10.1016/j.celrep.2018.11.007

    High-resolution analysis of the pneumococcal transcriptome under a wide range of infection-relevant conditions.

    Aprianto R, Slager J, Holsappel S, Veening JW.

    Nucleic Acids Res. 2018 Nov 2. 10.1093/nar/gky750

    Deep genome annotation of the opportunistic human pathogen Streptococcus pneumoniae D39.

    Slager J, Aprianto R, Veening JW.

    Nucleic Acids Res. 2018 Nov 2. 10.1093/nar/gky725

    Function of BriC peptide in the pneumococcal competence and virulence portfolio.

    Aggarwal SD, Eutsey R, West-Roberts J, Domenech A, Xu W, Abdullah IT, Mitchell AP, Veening JW, Yesilkaya H, Hiller NL.

    PLoS Pathog. 2018 Oct. 10.1371/journal.ppat.1007328